Superbugs, also known as drug-resistant bacteria, pose a growing threat to global public health, with projections indicating that more than 39 million people could die as a result of antimicrobial resistance (AMR) by the year 2050. This alarming prediction comes from a new global analysis conducted by the Global Research on Antimicrobial Resistance (Gram) Project, published in the Lancet.
The Growing Threat of Superbugs
The study found that while deaths linked to drug resistance are declining among very young children, driven by improvements in vaccination and hygiene, the opposite trend is observed among older adults. By the middle of the century, it is estimated that 1.91 million people annually will die worldwide directly due to AMR, up from 1.14 million in 2021. Additionally, AMR is projected to play a role in 8.2 million deaths annually, up from 4.71 million.
Dr. Mohsen Naghavi, the author of the study and a researcher at the University of Washington’s Institute of Health Metrics (IHME), expressed deep concern over the increasing resistance to antimicrobial medicines. He emphasized the urgent need for global action to address this significant threat to public health. The findings highlight the long-standing global health threat posed by AMR, which continues to escalate.
The Impact on Different Age Groups
The study revealed a significant decline in AMR deaths among children under 5, from 488,000 to 193,000 between 1990 and 2022, with a further expected decrease by 2050. However, while deaths due to infection in young children are decreasing, they are increasingly being caused by drug-resistant bacteria. On the other hand, death tolls are rising in all other age groups, particularly among the elderly.
Dr. Tomislav Meštrovi?, an assistant professor at University North in Croatia and an affiliate associate professor at the IHME, explained that the trend of increasing AMR fatalities among the elderly is attributed to rapidly aging populations. Older individuals are more vulnerable to infections due to chronic diseases such as diabetes and heart disease. Additionally, older people often require more hospital care, which increases their exposure to drug-resistant bacteria.
The Role of Global Leaders and Actions Needed
Global leaders are set to convene in New York to discuss antimicrobial resistance during the upcoming UN General Assembly. It is expected that they will reaffirm a political declaration aimed at intensifying efforts against AMR, with the hope of reducing AMR-related deaths by 10% by 2030. The study underscores the urgent need for better prevention of infections, improved access to healthcare, and the development of new antibiotics to combat the growing threat of superbugs.
The study projected that the highest numbers of future deaths due to AMR would occur in South Asian countries such as India, Pakistan, and Bangladesh, as well as other parts of southern and eastern Asia and sub-Saharan Africa. These regions have already experienced significant growth in AMR and stand to benefit greatly from enhanced infection care and broader access to antibiotics.
In conclusion, the threat of superbugs and antimicrobial resistance poses a serious challenge to global public health. Urgent action is needed to address this growing crisis and prevent the projected 39 million deaths by 2050. Collaborative efforts from governments, healthcare providers, researchers, and the public are essential to combatting the rise of drug-resistant bacteria and safeguarding the effectiveness of antimicrobial medicines for future generations.
